Autologous stromal vascular fraction therapy for rheumatoid arthritis: rationale and clinical safety

International Archives of Medicine


International Archives of Medicine 2012, 5:5 doi:10.1186/1755-7682-5-5

Jorge Paz Rodriguez ([email protected]) Michael P Murphy ([email protected]) Soonjun Hong ([email protected]) Marialaura Madrigal ([email protected]) Keith L March ([email protected])
Boris Minev ([email protected])

Robert J Harman ([email protected]) Chien-Shing Chen ([email protected])
Ruben Berrocal Timmons ([email protected]) Annette M Marleau ([email protected]) Neil H Riordan ([email protected])



Advancements in rheumatoid arthritis (RA) treatment protocols and introduction of targeted biological therapies have markedly improved patient outcomes, despite this, up to 50% of patients still fail to achieve a significant clinical response. In veterinary medicine, stem cell therapy in the form of autologous stromal vascular fraction (SVF) is an accepted therapeutic modality for degenerative conditions with 80% improvement and no serious treatment associated adverse events reported. Clinical translation of SVF therapy relies on confirmation of veterinary findings in targeted patient populations. Here we describe the rationale and preclinical data supporting the use of autologous SVF in treatment of RA, as well as provide 1, 3, 6, and 13 month safety outcomes in 13 RA patients treated with this approach.

© 2012 Paz Rodriguez et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.



These data suggest the safety and feasibility of administering adipose SVF intravenously. The uses of adipose stem cells have been reported in conditions as diverse as from hearing loss [152], to heart failure [153]. Given the anti-inflammatory, differentiation ability, and trophic factor production by SVF, we are hopeful that these safety data will support ongoing investigation into this novel and easy to access cell population.


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